I will bet at least a dollar that any new Colt will use drop in parts, have little or no hand fitting, and will have parts made by MIM. They might not have locks, but in a lot of other respects they will be a lot like ... well, S&W's.
If they decide to come out with a new design revolver, Colt would be well advised to concentrate on two areas, a small six-shot .38/.357 for concealed carry, and a medium frame .357 to compete with S&W, Ruger, and Taurus in that market. They should forget the .44 Magnum and bigger until they have re-established themselves.
I am not holding my breath, though. In the last 50 years, Colt almost totally gave up the civilian market, telling us that they didn't want to arm civilians, only the police and military. I heard that a former Colt president spent part of his first day tearing the NRA sign from his office wall, and ranting that he wouldn't make guns for "gun nuts and NRA thugs". Nothing like cutting off one's nose, but they thought their future was assured with the M16 and they could gouge the government forever. Didn't work.
Jim