"The table below shows the Hatcher "Relative Stopping Power" index for several comparative rounds as well as the .45 caliber Colt and S&W loads. While this is not an exact statistic it does help to put things in perspective.
Cartridge...............................................Hatcher RSP*
.380 ACP 95 gr JHP @ 900................................9
.38 Long Colt 148 gr LRN @ 760.....................11
9 mm 124 gr FMJ RN @ 1150...........................13
9mm 147 gr JHP @ 950...................................15
.38 Special 158 gr LRN @ 790.........................13
.38 Special 158 gr LSWC-HP @ 915................18
.357 magnum 125 gr JHP @ 1400...................20
.40 S&W 180 gr JHP @ 950.............................25
.45 ACP 230 gr FMJ RN@ 850..........................28
.45 ACP 230 gr JHP @ 850..............................35
.45 Long Colt 250 gr LRN @ 850.....................38
.45 S&W 230 gr LRN @ 770.............................32
* Modified "short form"
For those more scientifically inclined. Source
http://home.sprynet.com/~frfrog/colt1873.htm
So, if anything is gonna knock you down, it's gonna be a 1911 or an old SAA