I also like to look at firepower capacity in relation to caliber used. Unless we are talking about very small deeply concealed weapons where a compact Glock IWB carries 6+1 of .45acp and an even smaller/lighter LCP carries the same capacity in .380, one has to look at the amount of available rounds in the carried gun as well.
I been told by a few law enforcement professionals, rightly or wrongly, that if I am in a dire situation and the immediate safety of bi-standers is not a concern I should empty my magazine into my target. When asked, "I was scared for my life, and pulled the trigger until the gun stopped firing."
While that might be sound advice for a very novice gun owner in a home defense situation, I think that as a responsible gun owner and daily carrier out in public that well placed and controlled shots until the threat stops (1 shot or 20) is to be striven toward. As stewards of our 2nd amendment right, we should be concerned not only for our own well being but the lives of the general public. It's no less tragic if I shoot the guy that was going to shoot me if I drill an 8 year old in the head with a careless shot.
That said, hypothetically lets say you only hit 60% of your shots on a target at center mass. I'm talking total non-grazing misses. If you have chosen to carry 8 rounds of .45 or 18 rounds of 9mm, you're talking about 5 hits compared to about 11. Does this make a difference? Probably not, but I suppose it could.
But, once again, I feel comfortable in my skill regardless if I am carrying a single .38 snub, a hi-cap 9mm, or a full sized .45. I try to weigh out my probabilities to see what makes the most sense (going uptown for lunch or downtown after dark) and carry accordingly. I just like to be proficient with numerous calibers and guns, just in case.