Say what? That's like asking who is the hottest and best looking female actress...Whats the best looking sixgun of all time?
In my mind's eye, there are three contenders, all from S&W:
1. The 3 1/2" .357 Magnum
2. The 4" .44 Magnum
3. The 2 1/2" Combat Magnum
the 6" Python gets honorable mention....
Personally, the Colt Anaconda though the Taurus Raging Bulls and the Ruger Security Sixes are also high on the list.
This threads sort of a timeless beauty kind of thing not which pistol you would feel most comfortable dragging behind you with a string.