I have a Kimber UC II, I'd be lying if I said I didn't notice the difference in felt recoil and sight alignment, it's there but it is both managable with practice.
That being said, the first thing I did was add a beveled mag well extension so the grip didn't dig into the palm too bad, and next I am adding night sights. So just make sure you have the sights on purchase, or the first time you are in moderately poor lighting or your target is dark you will be hoping you have alot of practice in and your aim is becoming a natural thing.
Of course I carry 14 ounces less steel on my hip and I like that alot. That's almost the weight of my wife's SIG P238.