Its all about personal preference....
That being said, go with the Ruger. As long as you can live without the 4 clicks sound (and are you really buying a revolver for the sound it makes cocking it?), Ruger is the best choice, overall. Price, American made, strong (durable), safe, and as accurate as you are, and then some.
I have had a 7.5" Blackhawk for over 25 years, and love it. Recently got a 5.5" new Vaquero, and I am having a bit of an "adjustment" to how small it seems. I have never owned an original Colt.
I had a Vaquero (not New Vaquero) in .44 Mag, but for that round, I prefer adjustable sights. Size and weight of the Vaquero is the same as the Blackhawk, which is larger and heavier than the Colt. The New Vaquero is the same size and weight as the Colt.
While the new Vaquero is too light to handle the "Ruger Only" loads made famous in the Blackhawk, its no slouch. All regular .45 Colt ammo will be safe, and if handloading, a 250gr bullet at 1,000fps (max for the Colt SAA) won't hurt the Vaquero, even if it does get to be a handful in the light gun with its small grips!
I wouldn't go over that level, though.
Also, since you want fixed sights, you are going to be limited to the "standard" 250gr bullet if you want impact to be close to point of aim. Heavy bullets currently popular for some hunting won't be a good idea in a Vaquero, because of their different point of impact, and because you cannot safely drive them fast enough to get their full benefit. Light bullets at speed will also not print at point of aim, but reduced speed loads should be close enough.
Ruger's trigger is easily tuned, if its not good enough to suit you the way it comes from the factory.
You can spend $1200+ and get a recent production Colt, or USFA (didn't they buy Colt's horse?), or you can spend less than half that for a Ruger that looks nearly the same, and has coil springs and a transfer bar safety system allowing safe carry will all six chambers loaded.
One word of warning, about the early new Vaquero's case hardening. Several reports have shown up on the net about rusting problems with these guns. I live in a dry area, and have had no rust issues. Also, apparently Ruger has changed how they finish their blue guns in the last couple years, as there have been no reports (that I have seen, anyway) about any rusting problems lately. It is possible that the problem was confined to a single batch of production, as it hasn't been reported lately.
I would buy a Ruger (again
), because they are a good value for the money, a solid product, and they are American made. SO my money goes to American workers, not just the Americans importing foreign made guns.