I got a Python back when they first came out. Mine had the 6" bbl and was too muzzle heavy for me. I could not shoot it well.
My buddy got a Ruger at the same time in 44 mag. He shot hot loads and he could outshoot me in every way. At cans and targets at the old outdoor range.
He never had a problem with his Ruger. I got a Blackhawk then in .45 Colt and loaded it hot and it's still going strong. I settled on a 240 linotype SWC over 9.5 gr of Unique. That load is so effective and yet not punishing to the hand.
Recoil from a SAA type grip rolls the barrel up, it's easy on the hand.
The Python also spit lead from the front of it's cylinder. Then the forcing cone split open on the barrel. Colt put a new one on for free.
Then I got a Colt New Frontier 44 Special. I like that gun.