Indeed.
Know the machine. Know the limits. Understand whether it's an actual risk, or just a departure from standard procedure because you're not dealing with a 'standard' situation.
A Browning Buckmark has grip panels that are critical to retaining full function, but not critical to safety. (They hold some of the parts in place.)
Ruger 10/22s and Marlin Model 60s are similar. The actions will function and fire without the stock, but the stock keeps some of the bits and pieces from falling out.
The top cover is not necessary for an AK-47 to function. But it is necessary for an SKS to function. Different designs, different requirements.
I own a Ruger 77 Mk II in 7x57mm. I will tell you, without hesitation, that I do not stop at published maximum charges with most load data sources. More often than not, I check my usual data sources to see what powders seem to be preferred, and then fire up QuickLoad to see how much better the performance can be while remaining under a pressure level that I feel is safe. ...Because most sources, like with 8x57mm, limit their data to somewhere between 36,000 psi and 42,000 psi; even though SAAMI MAAP is 51,000 psi.
I know the cartridge can handle it. I know the rifle can handle it.
BUT I do that ONLY for that rifle. I have other 7x57mms here, and I do not believe that they could handle full power ammunition for very long. They get anemic, low pressure ammo that is loaded specifically for those rifles.
The 77 Mk II gets ammo loaded and marked specifically for it. The others get ammo loaded and marked specifically for them. And, loaded to the "lowest common denominator", at that - a 1916 Spanish Mauser.
(The 77 Mk II 7x57mm has a "twin" that lives right next to it in the safe, chambered for the 65,000 psi .270 Win. ...But I do NOT exceed trustworthy published max loads there.)
Know the machine. Know the limits. Understand what you're dealing with.
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It has been suggested that the 'fired without a barrel nut' concept be applied to a Savage-style rifle, with the threads removed. -- In essence, a smooth receiver ring and smooth barrel shank, with no means of mechanically locking the barrel into the receiver. The idea being to test Ackley's theories of chamber friction and bolt thrust.
But I don't see anything good in a test like that. All I see is case failure and unnecessary risk of personal injury.