-If that was a .45 cal rebar...
Every psychology textbook on the planet relates the tale of the (English? Welsh?) miner who took a drill rod through the head and lived out the rest of his days. It was
much bigger around than .45". Luck of the draw...
I seem to recall an elderly, arthritic woman in Miami who shot her (much younger) abusive boyfriend three times COM and killed him deader than a hammer after he'd kicked down her front door and attacked her. The caliber? .22LR. The Weapon? A Roehm RG-14. (The local DA charged her with murder, of course. The DA? Janet Reno.)
And .25ACP? I believe that, just here recently, a certain Florida teacher's last words were: "Why, Nathaniel Brazil, that's just a .25! I read on TFL that you couldn't hurt a fly with those!". BANG! End of story.
If you are relying on a super caliber, master-blaster pistol or wonder bullet to do all your work for you, you are putting your faith in a place that'll get you killed.
Shot placement, shot placement, shot placement.