I have .223 Rem, .22-250 Rem and .270 Win. rifles, but for range fun I still enjoy the .22 LR. I can shoot more, it costs less, and I don't need to handload! Barrels don't even heat up, unless shooting extended rapid fire strings.
Believe me, it's as tough or tougher to hit a silhouette at say, 150 yards with a .22 LR sporter than it is to hit most targets with a centerfire out to 500 yards. Wind can really make those little pills dance. Wind flags and doping the wind are really necessary.
Even rimfire benchrest at 50 yards is a tougher game than centerfire benchrest at 100 and 200 yards because the bullets don't behave the same as supersonic centerfire bullets in the wind. Not only do they deflect horizontally, but somewhat vertically, both above and below the zero, depending wind angle.
Picher