I'm originally from NW Indiana and I know all about the raccoon infestation. We'd get them as big as a medium sized dog, or close to the 50 to 65 pound range. When I had just gotten my license I hit one with my folks' 1 ton Suburban, and it felt like I ran into massive chuckhole in the road.
Now that I'm living near Boise, we have literally tons of whistle pigs out near Parma and we can kill upwards of 200 per person on a 6 hour walk through of the dunes. 10/22 with high-caps and a couple bricks per person with a shared speed loader are the norm, with a few varmint accurized .233 rifles for some long range (200 to 500 yards) work is pretty regular as well. Most of the .233 users are using hollow points and soft points.
I guess I need to get a scope now too .....
For regular hunting I would use regular hunting ammo, but for varmints as long as the kill is clean then I'll use anything.
Kris