A pistol will never again be my first choice to shoot a varmint. I found this out last year when I tried to kill a woodchuck that was tearing up my wife's garden. I had to empty my S&W revolver loaded with .38sp swc to get him to stop kicking. I hit him every time, too. The last shot was in the top of the head. That did it. I am not at all proud of that episode. After that I found that a 20ga shotgun with #6 shot at 25' does the trick every time. Critters are tough and anything less than a headshot usually won't put them down quickly. Shot placement is more important that what gun you are using. Even a lowly .22 LR will put down a big animal with proper shot placement to the head. It is always the Indian, not the arrow.