I've never used it myself, but Hodgdon lists plenty of loads on their site. QuickLOAD thinks about 30% is going to be blown out unburned from a 7½" barrel using a 240 grain bullet. More with lighter bullets, less with heavy ones. So it'll make lots of fire and not be very clean.
It's been a very good powder for me in 44 mag. As always, use the manual for a starting point and work up from there, watching for signs of over pressure.
My M29 is noticeably more accurate with IMR4227 than 2400. Velocity is lower, though. I never shot anything in full charge magnums but 250 gr Lyman/Keith SWCs.
Yes, I have tested from 17.0g (1007fps) to 23.0g (1250fps) under 240g SWC in a 6 1/2" BH. Have not marked any load as an accurate (or inaccurate) load, so must have been just ho-hum . Wasn't until I hit 21.0g (1139fps) that the SD dropped below 20fps. Use a Magnum primer of course with this powder.
I load 23 grains of 4227 over a Winchester large pistol magnum primer. It is topped with a 240 grain Nosler JHP bullet. I believe this gave me around 1250 fps out of my S & W 629. It's a fairly stout load and shoots quite well. I like the fact that it is very clean in this gun.
I used 21 Gr. of IMR 4227 for years shooting IHMSA stuff. It was my best load for a 10 1/2 inch Super Blackhawk using 240 Gr. Hornady. A lot of the guys used heavier loads, but I never had any problem knocking down 200 meter rams with it.