For my .243 I have tried:
IMR 4064
Hodgdon Superformance
IMR 4350
Varget
IMR 4064 and Varget are my best powders so far.
Shooting 100 grain Hornady Interlocks, IMR 4064 made a mockery of Superformance in accuracy. IMR 4064 and IMR 4350 had very little discernable difference, I do not however have a chronograph. I stuck with IMR 4064 due to needing less of it, as powder can be hard to find here too.
For lighter coyote rounds I like 70 and 80 grain Nosler Ballistic Tips, with either Varget or IMR 4064 for powder, with a slight accuracy and velocity advantage to Varget.