My problem is that I don't buy the argument that kinetic energy is the be all and end all of rating a cartridge's effectiveness.
Whether it's a 10mm 180gr at 1250fps or a .45 185 at 1150fps, I doubt a, say, groundhog shot with it would know the difference. For all practical purposes, this is the same round.
Then there's the matter of going up in bullet weight. There simply is no 10mm bullet comparable to 250gr .45 slugs. It's not that hard to get 900fps from these bullets in .45ACP.
You could probably make an argument that the 10mm has a slight edge in trajectory. Then again, I've shot both at 100yds, and it's not THAT much different, assuming relatively fast loads in both. Yes, the 10mm (and 9mm for that matter) shoot a little flatter.
I just don't see any practical difference in them.