I once hunted with a .22-250 and got several deer with it, but one day, was walking through the woods and saw a doe coming, so got behind a hardwood tree and waited until it was about 50 yards away and broadside. I noticed it was limping on one front leg, so didn't want to spoil a lot of meat and decided to shoot it in the head.
Well, I fired 5 times at the head, but as it limped, the head bobbed up and down, so I never hit it. Had to reload and shoot it through the lungs. What a frustrating experience!!!