I answered "no," but
then again, my usual CCW is a Sig C3 1911, with thumb safety.
I really don't mind a frame mounted thumb safety; it's reflex to me to take it off safe during the draw.
I don't like slide mounted safeties, in general. In my experience with them (primarily Berettas), they take just an instant more effort to manipulate, as flicking my thumb up and away from my grip feels much less natural then pulling it down and into my grip. This is not to say that they don't work, and I must admit I enjoy watching the firing pin of my Beretta rotate offline when I put it on safe, but that for me it takes just a slight bit more concentration to use them.
In an SD scenario, the less concentration needed on the weapon itself, the better.
So, the thumb safety on my 1911 isn't really an issue. For an SD gun, it edges my P220 because its slimmer profile and smaller butt let it conceal more easily. I prefer both over my Beretta because I like the P220's decocker and the 1911's frame safety better than the slide safety on the Beretta.
Cheers,
M