Every minute detail is worth compensating for at extreme ranges, 1/4" here, 1/2" there doesn't seem like much at 100 yards, the ranges the OP is talking about by considering the curvature of the earth is a game of hairs, everything that may potentially affect the POI must be considered to have even a remote chance of hitting something at such long ranges with any semblance of consistency. Horizon, mirage, humidity, target location in relation to backdrop (target without a backdrop may seem farther than it is, potentially causing over-compensation for range. Look at most (not all) Easterners hunting the west for the first time, usually shoot over the backs of their first few targets and that is generally only a couple hundred yards) There are many things that people do not consider in long range shooting that are a must for accuracy.