Honestly, if you're carrying a firearm for the purpose of self defense, you should be practicing hitting your target without using sights to aim. In the event that you need it, you're not likely to be lining up the sights on your target, but more likely pulling, pointing, and pressing.
Learn to hit what you're aiming at with your daily carry the same way that you point your finger... your finger doesn't have any sights on it.
But that's just my opinion.
When considering a typical distance in a SD situation, and the size, weight, and velocity of a typical 44 Special bullet, how important is expansion? Probably not as much as one might think.