I bought a S&W 351PD a couple years ago, and immediately bought a pair of Crimson Trace Grips for it. I noticed as soon as I took the gun to the range it was shooting about three inches to the left at 25 yards with the iron sites. Thank goodness for the Crimson Trace Laser grips, I zeroed it in to hit point of aim at twenty five yards, so it's just a bit off at 20 feet. I didn't mention yet this gun shoots 22 mag cartridges, it's noisy and has some muzzle flash, but I love shooting it. My wife does very well with this revolver also, but she isn't used to using the CT grips. I don't know how well one of these guns in a 22 Mag would protect you, but I understand this cartridge will shoot through a bullet proof vest, I don't know if that is truth or fiction. The one thing about this gun I don't like, it holds only 7 catridges and would be slow to reload. One thing I know, a 22 will definitely end a life. Years a go I investigated a shooting and viewed the body of the victim who took one hit from a 22 in his chest, near his left nipple. Only one small black dot was visible on his chest, and there was no exit wound. A well placed hit is deadly with almost any cartridge., with the exception being a 25 Auto. I say that from experience.