I think the first question you need to ask is "what exactly are you trying to achieve?"
I have a .350 RMag that I load. The first thing I wanted was a lightweight plinker/light hunter...the second thing I wanted was a middleweight hunting load...third, a heavyweight hunter.
Now, admitedly, the .350RMag is a limited cartridge. There are only about 10 common bullets made. 2x 180's, 3x 200's, 2x 225's, and 2x 250's. After them you get into the Barnes X bullets, the Speer Trophy bonded, and NorthFork bullets. Stuff I really don't want to shoot if I don't have to (a buck a bullet hurts!)
So I pick the bullet/s I want to start with:
180 gr. Hornady pointed soft point.
200 gr. Remington CoreLokt.
For powders, IMR is always a good starting point. I prefer to start with a powder that is "middle of the road" in terms of powder burn rates. IMR 4895 is dead center in the middle of the rifle burn rates and is just about as universal a rifle powder as it gets. It's much like Unique in pistol cartridges. It'll do a bit of everything.
I then try a long burn spherical powder as my second choice. Hodgdon H380 was my second choice by coinflip. Slow burning sphericals tend to be extremely consistent. Win 748 has a good rep as well.
Primers? I reach for Federal. I don't bother with anything else.
I seat to either the canlure or maximum recommended "book length". In this case the .350 RM is a 2.800" max length...
Next thing I do is load three rounds of each load. I do this is in "10 load indexing".
Example: for the 180 gr. bullet, H380 loads from 54 grains to 63 grains: a difference of 10 grains. 10/10 = 1 grain differences. So I load three rounds each of 54, 55, 56, 57, etc.
IF the load was from, say, 56-60 grains, I'd load 10 loads in 1/2 grain increments.
Go out and test for accuracy and pressure signs. If I see any accuracy trending (ie: grain loads from x to y are more consistent than other loads) I retest only around the accuracy trend in tighter margins.
I am after 3/4" groups with the .350RM at 100 yards. I've found that 4895 and H380 deliver the accuracy and deliver the punch I want.
Anything beyond that is just "foolin around"