I find the .45LC to be a great handloader's round.
I have found the following loads in different manuals/manufacturer's websites, and have used the "low end" of all except for the 225 gr load (I didn't have any 225 gr lead bullets).
I am far from an expert, but they appear more substantial than "Cowboy Action" loads, but nowhere near "nuclear" loads. They seem very reasonable to me. Can't speak to the upper end of any of them, yet. I use an S&W M-25, for what it's worth.
200 gr SWC, 7.3 gr 231 (8.3 gr max)
225 gr SWC, 6.5 gr 231 (7.2 gr max)
250 gr SWC, 7.2 gr 231 (8.0 gr max)
250 gr SWC, 6.5 gr Green Dot (9.4 gr max)
255 gr SWC, 6.1 gr 231 (7.0 gr max)