Did your friend remove the nipples prior to shooting? As in, when he cleaned the revolver before shooting? My guess is that if he did and he removed the nipples, he never tightened them up with a nipple wrench. Of, if he didn't remove them, he never checked them as "from there factory". If the nipples are the correct size, there shouldn't be a problem around the threads when seated tightly. On a Remington cylinder, the nipples fit at an angle so I believe that if not seated properly, the cylinder would still turn. On a Colt, if not seated correctly, there wouldn't be room between the recoil shield and the capped nipple and you would get cylinder bind.
Also, was he using caps that fit tight to the nipples and were the correct size for the nipple?
In over 50 years of shooting C & B, I have only seen two chain fires (while watching others shoot). One on a '51 Navy and the other on an original '58 Remington. The faut traced back to the Remington was due to modern nipples in the original worn oversize nipple holes in the original cylinder. Cure was to re-do nipple holes in the cylinder and use nipples with oversized threads.
Everyone uses different things on their nipple threads. All I do is apply a drop of 3 in 1 oil on the nipple three and seat them "tightly' with a proper fitting nipple wrench - and it's important to use a correctly fitting wrench. I don't remove the nipples each time that I clean - I do perhaps ever half dozen times I shoot. Again though, correct fitting threads and seated tightly, there should be no problem with that being the cause of chain fire. Moral of the story . . . "make sure your nipples are tight".