Road Clam,
One year ('93 or '94) I shot some poor-fill loads of Accurate 2520 in 308 just to try it. Groups out of the M1A opened up about 40%. However, that year I decided to try flash hole deburring, and when I did that, the groups tightened back down to the gun's usual ¾ moa (10 shots). I've never had flash hole deburring make any difference in any other combination in that or any other gun. Also, the primers I was using back then were not magnum primers, and moving to magnum primers might have done the same thing, but I don't know, as I gave up on that powder after the first pound was gone as being too finicky compared to the usual stick powders.
The reason I mention all of that is it proved to my satisfaction that ignition consistency was the real issue rather than powder space. Powder space makes ignition consistency harder to achieve, and that's why the correlation appears to exist.