Well my dad has a super hot rebated crimp 300 grain load for his hunter model that I refuse to fire in my Vaquero. Why? He was literally unscrewing the barrel shooting the stuff.
He finally wised up and backed the load off a bit.
It's possible to blow up any gun handloading, even the mighty Rugers.
Still, with factory ammo, your .44 was built to be a .44. Shoot it.