I spent several hours one evening reading various forums and watching youtube videos on these.
My opinion, they were designed purely to do well in ballistic gelatin, appearing to create that "hydrostatic shock" that fast moving rifle rounds can create. I have a hard time believing that the damage shown in gelatin translates to a human though.
You have to remember that ballistic gelatin is just the best representation we have today of a human body, but at the end of the day it's still a very constant block of goo.
On the other hand the inside of a humans is anything but consistent, where a bullet could go through skin, bone, muscle, fat, and several different very different organs.
I guess if you were going to load your handgun with ball ammo anyway the LeHigh MIGHT perform a little better than that in the real world, but I still have my doubts.