Well I own a gun of that same size and type in 357, a Ruger NewVaq. 38 and 357 will shoot to a very similar point of aim as long as the bullet weight is the same or at least similar (you won't be able to notice the difference between, say, 135gr and 140gr).
You'll be able to shoot the stoutest 357s made by smaller radical ammo houses like Buffalo Bore, DoubleTap, etc. Your cylinder will have more "beef" in every direction than a GP100 or S&W L-frame so the gun won't be the least bit weak.
You *might* want to swap to US-made springs. If you can afford it, Longhunter's pre-tuned version of the El Patron is pretty nice:
http://www.longhunt.com/taylor/smokewagon.htm
This is also an Uberti-made gun at the same level of finish as the El Patron and *then* a very well respected gunsmith does some magic on it.
Ubertis made in the last 10 years or so are very respectable guns. They lack a modern safety so they're safe carried five-up only. Uberti's version of the transfer bar safety comes with their Beretta-labeled variants, but those aren't as successful - the action is weaker and the SASS people have been complaining about failures with high round counts. The Ubertis without safeties including the El Patron and Smokewagon hold up better.