Most slugs are made to be fired in smooth bore guns.
The exception are the expensive "sabot" slugs. They are a smaller bullet wrapped in a plastic shell that is designed to be spun by rifling like a rifle bullet.
Then, there's the exception to the exception,
in that some sabot slugs (not many) can also be fired in a smooth bore gun and say so right on the box.
Then there's the other exception that some of the sabot slugs that "can't" be fired in a smooth bore gun will actually perform just fine in a smooth bore gun, particularly if distances are kept to typical smooth bore distances, like 60-75 yards.
Short answer: Yes, but just like a rifle there will be brands that your gun "just doesn't like" and brands that it will shoot lights out. You just have to try a few and see.