I haven't had a chance to handle one, in fact, haven't even seen one, so all my comments are general in nature.
I've never understood people's strong dislike of either a loaded chamber indicator or a magazine disconnect. I suppose there is some chance of losing the magazine but the loaded chamber indicator baffles me. Same with the safety. My own Ruger P345 has a safety on the slide, which is flat as it can be and works "the wrong way," so it frankly doesn't get used much. Either way, it isn't in the way and it has never been in the wrong place.
However, your feeling about the manual safety on a double action handgun are shared by others and you probably know that when the German police solicited designs for new standard police handguns, the specification indicated that there be no manual safety. Almost radical for the time, if you ask me. But for a country that had used double action revolvers for a century, it is surprising that all of the DA automatics had thumb safeties when they were introduced until recently. I don't know which was the first that didn't (and I wouldn't be surprised if it were a long time ago). In any case, I don't know if more safeties increase the possibility of failure but I understand what you are saying. There was a fad for a while to pin down the grip safety on Colt Government Models, too, and some similiar copies never had them, like the Star automatics. But what is the internal safety you are referring to?
Your comment about disassembly is also appreciated because I thought the Ruger .22 was the most difficult pistol to take down. Of course a Colt Government model isn't all that simple either.