I own two Ruger 10/22s. Accuracy is about 2 MOA at 50 yards from a bench using good quality, but not match grade ammunition.
There is no last round bolt hold open on the Ruger 10/22. The bolt catch lever that can be used to manually lock the bolt open is a bit tricky to master, especially when releasing the bolt. There is an easy modification that can be done to the bolt catch lever that will allow you to easily release the open bolt by simply pulling back and releasing the charging handle. You can find a number of how to videos on youtube. If you don't want to modify parts on your own, you can get an aftermarket bolt catch lever that does the same for around $10-12.
Earlier 10/22s had a magazine release button that was a bit hard to find quickly. More recent models have an extended magazine release lever that works fine. But if you don't like it for some reason, there are a ton of aftermarket replacement options.
The stock on the carbine is a bit short. I have two carbines, one with a wood stock and one with a synthetic stock. I added a slip-on Limbsaver recoil pad to the synthetic stock, and a John Masen recoil pad to the wood stock and now the length of pull is ideal for me.
In my opinion, the two biggest shortcomings of the stock rifle are the sights and the trigger. If you are young and/or blessed with excellent vision, you might find the sights satisfactory. But I cannot focus clearly enough on the small front bead to achieve consistently accurate sight alignment. The elevation adjustment on the rear sight is rather awkward to use, and there is no windage adjustment short of drifting one of the sights in its dovetail with a punch.
The stock trigger is pretty heavy. It is functional, but for accurate target shooting many Ruger 10/22 owners will have their triggers worked on, or buy a drop-in trigger assembly. Fortunately, there are a ton of aftermarket options available for the 10/22 and virtually every part can be replaced with a non-Ruger part.
A recoil pad, a Brimstone Gunsmithing Tier 3 trigger job, and a pair of TS-200 Tech Sights made a world of difference in the shootability of my first 10/22. The second one had a Brimstone Tier 2 trigger job and wears a riflescope mounted on the factory Ruger accessory rail.