A lot of leading factors depend on the firearm and the bullet.
In general:
If you push a soft alloy too hard, it will lead.
If the bullet diameter is too small, it will lead.
If the bullet diameter is excessively large, it will lead.
If the cylinder throats or forcing cone are smaller than groove diameter, it will lead.
Right now, in 44 caliber, Hornady 240 gr SWCs outnumber all of my other bullets by a factor of about 5:1. It's a really soft bullet, by most standards (BHN ~8), but I really like them in light loads to light mid-range loads in .44 Mag. However, they lead like a sum-B if I push them too hard.
Edit: I took too long to post.