As you know I have a NewVaq357 and love it. Had it since 2005, been modifying it since, it's now turned into a real beast complete with radical sight experiments:
http://www.flickr.com/photos/1jimmarch/3617053759
THAT SAID, at the time there were very few 50th Anniversary 357s around, basically the same gun but fixed-sights, all-blue. They were also expensive.
They're not expensive no more - $400 gets one from here:
http://www.cdnninvestments.com/dowournewcat.html
That's a better deal than $500 worth of NewVaq.
Here's why:
* Only the very newest NewVaqs are all-blue, no fake-case-colors anymore. Trust me, the fake case colors were a very bad idea. It rusts unless you watch it like a hawk - as in daily checking for me during the summer in AZ when I run a swamp cooler. I catch the first light dustings of rust and it wipes right off, thankfully, but it's a pain. The blue barrel and grip frame isn't doing that. All of the 50th guns are all-blue.
* Adjustable sights on the 50th. It would be pretty easy to put REAL Goshen Hexsites on a 50th 357, and even retain elevation adjustments. Take the rear sight out, cut off the back end where the blade is, tap a hole in the sight body for the Glock-variant Hexsite to bolt onto. Easy. All kinds of other sight options too, without getting into the "weird science" I've done. Mind you, I've had fun and I like how my sights are coming along, but it was a hell of a pain
and I'd never have gotten the latest incarnation right without a trip to Sedona AZ and a visit to Tim Sheehan's shop for his help tuning what I was doing. (The guy is seriously cool.)
If you don't go the Hexsite route there's tons of others - look at the parts area of Bowen's website for target, "combat" and "V-notch" options:
http://www.bowenclassicarms.com/parts_Rug_Rough_Country_Adj_Rear.htm
If I wasn't going the Hexsite route, I'd likely do Bowen's Express-V rear and XS Big Dot front...and that's just catalog bolt-on parts with the 50th 357. (But the Hexsite is better!!!)
What else...ah. Recoil control. Identical in both guns - same heft, same grip. Same grip panel options. With the nastiest 357 ammo possible, shooting one-handed, either gun is controllable BUT you'll want smooth grips instead of the "black cheesegraters" on there. I just sanded down most of the factory grip panels and rounded the bottoms, and while it looks cheesy it works so well I never bothered to upgrade. If you haven't figured it out by now, I care about how it works, not how it looks
. That said, similar wood grips are easy to get for either gun.
I recommend a "pinkie under" hold, and you should be able to comfortably reach the hammer from your strong hand without shifting the grip. In my case, to do that I dropped my hammer reach by adding a SuperBlackhawk hammer.
It sounds like your hands are smaller than mine. To see if my route would work, go find a Ruger "Montado" at a dealer and see how that feels - the hammer is the same as the SuperBlackhawk but with a different checkering pattern - reach is the same. (The Mondado is a NewVaq with a short barrel and hammer swap just like I did in 2005.) If the Montado still feels funky, no problem, it means you'll need to buy a Ruger Bisley hammer from Brownells instead of the SBH like I did. The Bisley hammer fits, except you have to tweak the back edge just a little to make it fit non-Bisley grip frames. It's not a "gunsmith required" trick, a few seconds on a grinder will get you there. Let us know if this is an issue, I'll find you a link on what to alter. You're NOT changing the safety-critical sear surfaces or anything else needing tight clearances. Short form, hold the Bisley hammer flat against your stock hammer and you'll see right away where the rear "bulge" is on the Bisley hammer that needs trimming. Easy.
You need to be able to reach the hammer strong-side-only. There's techniques for shooting two-handed, cocking with the off-hand. Don't go down that dark path - it can get you killed in a real fight where you only have one hand available. Tune the gun's ergonomics to your hand. It frickin' ROCKS when you do.
If you're going to take your Ruger boomthing apart, get a set of gunsmith-grade screwdrivers or bits. Brownells has a Ruger-specific set for cheap. Highly recommended, along with blue locktite on critical screws. NOT FOR THE LOVE OF GOD, RED!!!
Two-handed, hot 357s can be controlled in these guns bone-stock unmodified, but the grips are still uncomfortable (checkering again).
See this thread pages 2 and 3 for my notes on why the Ruger mid-frames rule:
http://rugerforum.net/showthread.php?t=16139
You've probably already run into a version here.
Again: the NewVaq and 50th 357 are the same gun. The GP100 is available fixed or adjustable sights under the same name, these two SAs should have been as well.