I'm suprised at the number of people who write off the .250 Sav. with the lighter bullets on deer. I too once believed until I started hunting deer with a .257 Robt. After killing upwards of 50 whitetails and one mule deer, with bullets from 75gr to 120gr. I can tell you that the .250 will kill deer at least as well and usually better than the .243 with similar weight bullets. I've seen and have experienced bullet failure to expand with the .243 and bullets of 100gr. at ranges of 300yds and greater. Never with the .25's.
However, I have seen the .25/06 w/87gr. Rem PowrLokt bullet (factory load) wound a deer with a neck shot. It played dead for 30min. and then miraculously revived while truck it was in was parked in parking lot of County Court house. A .40 S&W sealed the deal though; -And an embarrased claim to StateFarm for the bullet hole in the bead of the truck! The bullet (.25) had hit the neck behind the skull and left a substantial flesh wound, but little blood and had only "knocked" the deer unconcious having missed the spine.
Make sure they aren't still breathing before you put 'em on the truck!
One night I was doing some permit control work on an airport and the person I was assisting was using a .243 w/Rem 80gr SP fact. loads (uncle of above .25/06 hunter), I was using the .257 w/ 75gr HornadyHP handload at chronographed 3520fps. The only difference was the .257 had a more pronounced "slap" when it hit at ranges over 100yds over the .243. All 11 deer we shot that night at ranges of 70 to 413yds (measured) died instantly. (Most were shoulder spine shots except one head shot), NONE of the 11 had bullets in them as all had completely passed through- they were cleaned and dressed at County Jail- made quite an impression on the prisoners !!!
The 250 Savage's I've shot were all accurate rifles including the Savage '99 that would shoot 1.5"/3-shots @100yds all day long with either 87,100 or 117gr bullets. A T/C contender w/14" bbl was another aquaintances favorite deer "gun", he likes the 85gr Nosler BT. I used the 85gr BT on a 200lb muley in Montana in '93 as I only took one ammo, shot other 96 of 100rds I took on prarie dogs- 3shots were used to verify zero. Bullet completely penetrated shoulder-spine @ measured 370yds (440 paces).
Trajectory of .250 Sav. is similar to .30/06 which is plenty flat. Power is not significantly below .257 Robt. or .25/06; and kills just as well as you can shoot it.
Get it and shoot it !!!
Don't worry if it'll kill deer, it will! And with all available weights of ammo.