.45 Colt is my favorite cartridge, but you have to reload to enjoy it.
Paying almost a dollar a shot for wimpy "cowboy" ammo (and even that is hard to find) sucks bigtime. I can load them for about 5¢ each with my own cast bullets, or 10-15¢ each with commercial cast bullets and load it to just about any power level. 250 grain bullets at 1000 fps is a really nice load, and an Anaconda should handle that easily. (I can load them up to about 1400 fps in my Ruger; I don't know if an Anaconda is stronger or weaker than a Ruger, but the fun wears off of super-hot loads really quick)
OTOH, there's a much better selection of .44 ammo available, and I've read that the brass lasts longer in a .44 before it splits.