The larger flash hole has the potential for changing the pressures dramatically. It may also change the back pressure against the primer causing primers to back out on you.
In my opinion, loading these with bullets would fall in the category of experimenting, not reloading. If you do proceed, you should NOT trust any of the reloading recipes from the manual.
Seriously, for whatever 100 pieces of 45 brass cost are you willing to experiment with the integrity of your revolver or body parts.
If I couldn't return them, I would crush them and dump them in the recycle bucket, or I would use them for shooting the primer powered plastic bullets that speer makes.
Edited: I just looked up the price on 45 brass. For $25 you can replace these with good brass. You can't even fill up your car for $25 (well hardly anyway). It's really not worth the risk to play with these.