Twist rate, powder charge, and bullet stability
Understanding the principles of bullet stability can help you make use of the large variety of .224 bullets available to the handloader.
For example, I have used a virgin case topped with Lil' Gun powder and 50 grain Hornady v-max bullets to fire-form Privi Partisan brass. It is necessary to cut off the plastic tips of the bullets to get them to stabilize in the 1-14 twist CZ barrel. This particular round is very accurate and I use it for fire-forming and kill shots on ground squirrels, feral pigeons, and rabbits.
A 1-12 twist rate would likely stabilize the same 50 grain v-max without having to cut off the tip. The nice thing about a faster twist rate is it allows you to run longer bullets at a slower velocity and still have the longer bullets stabilize in flight. Look online for a free internet calculator that will give you the minimum velocity necessary to stabilize a particular diameter bullet of a particular length.
I was able to stabilize the 50 grain Hornady bullet by shortening it (cutting off the tip) and raising the velocity with Lil' Gun powder.
Alliant's Power Pro 300-MP might be another powder for you to consider for your mid-range (velocity) 45 grain loads; powder volume will be less than 100 percent in the K-hornet case.