243?,308?,,Thats a tough one.In all honesty I think I would go with the 308 if I wanted the best chance, of the BEST accuracy.There would be no guarantee either way.Then again if you were talking the same rifle,The 243 would have slightly more meat in the barrel,than a 308 because of the caliber size.There is just no way to know or any guarantee..I would go with a fast twist 308 and load HIGH BC bullets for long range(Long range is what I enjoy).For you it would depend on what range you wanted your accuracy.Say 100 yard benchrest would be better off with a slower twist rate probably(again there are exceptions).My ar15 (fast 1-8 twist)is accurate at 100 yards with 35gr vmax bullets
.But is also accurate with 80gr smk at 100 yards.I have only proven that 77gr smk shoot good at 600 yards with my rifle.The 80's are handfed and I have not tried them at that range(YET!!
).Another example is the 6mm-6.5mm(243 area) are used for benchrest and LONG range competition.They are KING of the hill in accuracy
Have you considered those cartridges??6mm ppc or one of the other calibers in that ballpark?