My choice would be based on caliber more than handgun type (revolver vs. semiauto vs. whatever...)
The caliber would have to be good for hunting since I use mine for such - all hunting calibers would be acceptable if not ideal for self defense, but not all self defense calibers would be worth a hoot for hunting... So it'd probably have to be a .44 mag.
Now handgun type... Don't know, Desert Eagle's a little big to CCW and a Ruger Redhawk with better CCW possibilities is nonetheless limited to 6 shots, though a pair of speed loaders would make up for this a bit. Hmmm...
Gee ain't ya all glad we don't have to make such a silly choice?
(I didn't bother to vote as a means of protesting such limitations!!
)