Ruger strength
Compared to the Colt SAA and clones, the new Model Blackhawk, Super Blackhawk, and the (now called old model) Vaquero are tanks. The frames anre bigger and tougher, and so are the cylinders.
I have a couple of .45colt/.45acp Blackhwaks, and a .44 Mag Vaquero. No sane loading stresses these guns, and some insane loads can be handled as well.
I have been shooting one of my .45s since 1983, and after a period of seeing just how much of a magnum it could be, I decided I would rather have fun shooting without being beat to death when I pulled the trigger, and settled on a load that clocks about 1070fps, a 250gr hardcast SWC, pushed by Unique.
The load is on the top end of what used to be allowed for the Colt gun in the old manuals, and stresses my Ruger not a bit. Accurate too. Fun to shoot, delivering a fair bit of "thwop", without a punishing recoil.
You can hotrod a big frame .45 Rugers quite a bit, but if you want a lot more, you really should get a bigger caliber, now that they are available as factory items. remember that the folks who developed the hot loads did it mostly because bigger hotter rounds weren't available in those days.