The Black Hills Blue Box 75gr gets just under 2600fps out of my 16" barrels (about 2585fps to be exact). It is also one of the most accurate loads out of all of my rifles.
If you are concerned about terminal performance, it is one of the most tested loads out there with openly available ballistic gel tests of it going back a decade. The Hornady LE website also shows performance out of various barrels. I think it would serve well in a home defense role, though it can be a bit lacking in intermediate barrier performance compared to newer stuff that is barrier blind.