.50 Maxi's
I've not shot any hogs, but have used .50 caplock rifles on whitetails here using 370 Maxi's. In my little T/C White Mtn carbine I shoot 70 gr of FFFg, in the longer, heavier Renegade, I bump the charge to 80 gr'. I've had nothing but pass through's on the half dozen or so deer I've killed in the 125-150 lb range. I'd speculate that those 370 gr slugs were running near 1400 fps, and that's pretty serious medicine.
Hogs are reportedly a bit tougher than deer, but I cannot imagine one taking a well placed shot and expiring in short order.