pastime, I've loaded a lot of different cast bullet loads in the 45 ACP, everything from 155gr SWC for reactive steel shooting to 255 gr SWC for hunting.
Brinell hardness for the cast bullets I use ranged between 12 and 18, and I've had no real issues with leading.
That being said there's a lot of things that will contribute to barrel leading when using cast bullets besides the hardness of the bullets, the bore of the barrel itself, the bullet lube being used, the powder being used can all create issues.
The two choices you have listed should work equally well for target shooting and plinking, for self defense I would choose a bullet with the biggest meplat, in your case that would be the TC bullet.
However, keep in mind some will advise against using handloads for self defense against another human and their logic has merit.
If I was choosing a cast load in 45 ACP for self defense I would consider a box of Buffalo Bore 255gr cast FN 45 ACP +P loads with a MV of 925, as long as your gun will feed them well, mine do.
As for your question about a bevel base, it will allow the bullet to start in the case easier.
You still should bell the case mouth, I also like to lightly chamfer the inside of the case mouth of my brass.
When you crimp your loads make sure there is no bell remaining as it will cause feeding issues in a semi auto.
Best Regards
Bob Hunter
www.huntercustoms.com