Ok, it's a rainy day, so I'll bite...
I personally witnessed a friend roll a pitbull mix at an incredible range (circa 75yards or so) with a Kimber Custom Classic using premium 230gr JHPs of some sort. He maintains it was skill, I insist is was luck (it was a "you'd have to see it to believe it" type scenario).
But without a doubt, that .45acp turned him a flip from a dead run. I would bet he was long dead before he even finished rolling. Never in my life have I seen anything like it. He lost fewer chickens that year it turns out.
Personally, I've turned a feral tomcat into jelly inside the same friend's barn using Trition 115gr Quik-Shok from a K9. Had it been a dog, I'd expect the results to have been similar.
So, in my opinion, as I'm sure you've heard hundreds of times before, placement counts.