Best buy for the money? S&W 686 Power Port
Ruger GP-100's are good guns but, in general I find over time that I prefer the S&W in the same format because the Rugers are only slightly cheaper in price but, rougher overall (not just in the places you see on the outside). While the Ruger ads make a big deal about about their beefy nature - how many of us have broken a S&W? That's a good ad campaign but, only marginally valid in the real world - especially with the average number of rounds fired by the average user. If you are shooting 10,000 plus rounds a year, you will literally wear a gun out and durability aspects like this may have some valid merit.
S&W uses the proper materials for the job so, even though the top strap may appear to be weaker, it is made out of the correct steel for the intended forces and stresses and does not have to be that thick to do the job. If they used a different steel with lesser qualities, I'm sure it would be made thicker as well. I will also note, that if you had a problem (which is unlikely) S&W warranty and repair policies are very good and you will not be disappointed - they run a first class shop.
My S&W 686 Power Port has a six inch barrel with an additional half inch in front of the front sight with a expansion chamber and port to vent gas. That combined with the full under lug barrel and excellant ergonomics make for an extremely tame shooting pistol. You can shoot the nastiest recoiling loads in this gun without (at least in my case) sore wrists after a long hard day shooting (more then 6 hours and more then 300 rounds in one pistol). Quality control is very good and S&W does not cut corners in places where it is not seen by the average retail consumer - a quality pistol through out.
Colt - if you get past their anti-gun politics, bankruptcies, labor union troubles and, varying quality, you still have a company living on past glory and name recognition, not a company that can stand on its own merits in this century. The Python is a pistol that, when quality control is good, is an excellant target piece that works very well with light target loads. If you intend to shoot it a lot, especially with hotter loads (38+P & 357Magnum), plan getting it tuned up periodically. This pistol is known for being "soft". For a self defense or general hard target use pistol, I would look towards the King Cobra. You won't get that finish you can shave in or the best double action trigger in the country but, you have a hard use gun that will hold up much better over time. For the money though, personally I think the S&W 686 is a better choice with a near dead even tie between the King Cobra and GP-100.
With all that being said, your initial choice of a Ruger GP-100 is not a bad one. They are good solid pistols priced pretty good. I still have a strong perference for the S&W L-frame series in all its variations (Power Port, 7 shot "Plus", etc.) since they are priced so close to the Ruger and give you better quality. My advice on Colt is to pass. Colt is making a better product now and will re-sell well because of name recognition and, in general, an uninformed consumer is the most likely purchaser.
My thoughts are starting to stray off topic so, I'll close here for the moment.
Sid
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TX FFL dealer