For my normal .357 pistol load of a 158 grain cast bullet, I still like Unique at about 1,100 fps out of a 4" S&W. Not truly a hot load, but comfortable to shoot and very accurate out to a hundred yards or so.
Rifle wise, I've been using Hodgdon's Lil'gun behind 180 grain bullets in my Marlin 1894 rifle with exceptional results.
Over the chronograph it produces velocities well over a hundred fps faster than the other slow powders with seriously lower pressure and the ES and SDs are more consistant and lower too.
I haven't tried the load in my revolvers yet, but that project is on the radar screen for later this year. The Hodgdon's loading manual shows about equal velocity with H110 in pistols, but in the longer barrel of my rifle it is pushing the 180 grain Remingington hollow point at a true 1,700 fps.