When I was looking to get a new SA and a new to reload cartridge . .. I was seriously considering the 44 WCF just because of the historical nature of the cartridge. The more I looked in to it the more advice I got from some to consider a different cartridge due to the nature of the cartridge - as pointed out by 44 Dave. That's not to say it can't be done as a lot of folks do it and enjoy it.
I also looked into the 38-40 but decided to avoid that as well as I was advised by several of the same type of problems.
I went with the 45 Colt (which I had always wanted to reload) and I'm really enjoying it. I'll say one thing though for my Uberti 7 1/2" Cattleman . . . . the chambers are so generous on it that I'll never have a problem like 44 Dave is concerned with.
Of the several hundred rounds I've put through it so far, I have had to use the ejector twice - otherwise - open gate, hold muzzle up and rotate cylinder and they fall right out. The loads I'm using are very accurate and I couldn't be happier with the Cattleman but I'm kind of glad I went with the 45 instead of the 44 WCF.
But . . . the next revolver I'm looking for is one in 32-20 (32 WCF). I'm all set up with molds, brass, dies, etc. but just haven't located a revolver yet. From what some have told me - the 32-20 can be a "learning experience" was well. But who knows . .. if I find a revolver and can get the 32-20 figured out . . . maybe the experiences will help with a 44-40. What would life be without challenges?