If the grips are the same, you'll never know blindfolded. I have owned two Uberti .357 and a friend has a Colt. There may be differences in metalurgy, but as to fit and finish, the Ubertis were just as good as the Colt. Springs, etc, the Colt may be better quality and last longer, but for my purposes, the Ubertis are without flaw. For a more serious, dedicated SA shooter, the Colt may have advantages. As an occasional shooter, I couldn't see a difference.
However, I got quite the response when I took the Ubertis to my local bowling pin shoot. The guys with the STI and Kimber race guns really gave me some good expressions when I put my two nickel revolvers on the table. The auto guys got to use extra mags, the revolver guys got speed loaders, they ruled I could use two SAs, but I only had ten shots, while most everyone else had at least fifteen per round. Since we shoot the pins off a 4x8 sheet of plywood, sometimes the pins took an extra shot or two to get to the ground.