The answer to your question may only be conjured up via black magic or close thereto.
In most cases it doesn't matter much. EXCEPT when using compressed or maximum loads. Seated too deep and you may experience over pressures. Not Good.
COL is only a reference so that your rounds will work in most guns. Note I say most, not all. COL has to be less on some guns depending on bullet style.
Now if you like to tinker you can seat your bullets a few thousands in or out till you seem to find the sweet spot. Add this to finding just the right powder, load, primer, brass, phase of the moon, planet alignment etc. and much time can be wasted and not much achieved. Then when you try a different weight or brand of bullet, case, primer, install a new sling, or read TFL fourms you can start all over.
But to answer your question in somewhat reasonable fashion. Several thousands one way or the other doesn't matter to me, as long as I seat that batch the same depth. If the batch function properly, go bang and I have a decent group, I’m happy. Of course I'm not shooting off mosquito's wings at 1000 yards. If I was I guess I would just have to conjure up my COL sweet spot according to my daily horoscope.