I have been loading 40 grains of FFFg in the .45 colt, with a 250 grain bullet.
Wonderfully smoky and pretty good for accuracy.
They are a lot to fun.
I had to do a lot of research and get some help from the members here on TFL.
The most important thing I received from everyone who helped me figure out the load was: THE POWDER MUST BE COMPRESSED!
If you decide to use 35 grains, just make sure it is compressed. If you have to add felt wads to the top of the powder, do so. Make sure it is compressed.
Also, make sure the gun is cleaned very well after firing. I have a friend who shot these in his Ruger Vaquero and did not clean it. He said about six months later when he decided to clean all his pistols, he noticed slight pitting.
(Why does someone wait six months to clean a gun?)