I have a Beretta 950 BS, a Raven, an Ortgies Vest Pocket, and an old Gradoga. All in .25 ACP. The Ortgies and the Gradoga are most reliable with FMJ, while the Raven and Beretta feed Hornady, Winchester, and Glaser with no problem.
I'm a little hesitant to use the .25 ACP as a primary defense round. Having witnessed several shootings with it, I'm not at all impressed with it's ability to end a confrontation. However, in hot weather, it beats a hard look.